Alzheimer's disease in the first "kills" the sense of smell

Leonardo Beluš (Leonardo Belluscio) from the National University of neurological disorders and stroke in Bethesda (USA) and his colleagues came to this conclusion by tracing the development of Alzheimer's disease in mice, the genome of which has been built shortcomings human gene associated with the disease. This version of it occurs in patients with so-called "early" transmitted genetically, the form of the disease. According to enjoying popularity among medical hypothesis Alzheimer's disease is caused by the accumulation of pathogenic agents – beta-amyloid protein – in neurons. This peptide arises from the "scraps" of the protein APP, koy takes an involvement in the process of repairing the damaged neurons and the formation of long-term relationships between them. Abnormalities in the processing of "old" molecules of the protein lead to the appearance of beta-amyloid plaques and unisobstvennozheniyu antsy cells. Beluš and his colleagues have established itself in three weeks in a posledstviidstvii born mice with human APP gene have lost four times more olfactory cells the center in comparison with its "wild" neighbors. If this had been killed, not all cells, but any of them, in the remains of which there is a high concentration of protein APP. Thus, the data base of death of neurons were some internal processes, but not outside, as it were the appearance of amyloid plaques. Scientists think, actually pulling the cells were killed because of damage to the molecules of the protein APP, located on the wall koie these neurons. This conjecture is confirmed by the actual olfactory neurons die at a stop posledstviidstvii "off" the abnormal gene by a retrovirus. Biologists believe the actual blocking of APP protein may help get back on defense and other types of neurons. "The difficulties with recognizing and distinguishing odors are considered one of the first signs of Alzheimer's disease. These indicators have all chances to be accepted for service physicians for the early diagnosis of this disease, "- concludes Beluš whose words led public relations department of the Company neurophysiologists.