Researchers have developed a way for quantitatively assessing atherosclerotic plaque buildup in mice. They transplanted X-ray-irradiated low-density-lipoprotein-knockout mice with bone marrow cells expressing near-infrared fluorescent protein, which subsequently developed into fluorescent macrophages. These macrophages congregated particularly in atherosclerotic plaques that arose after feeding on a high-cholesterol food regimen. In vivo imaging detected the quantity of aortic plaque shaped and its change over time, which might assist in assessing the efficacy of anti-atherosclerotic medication.
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