Summary The pharmacology of anti-SARS-CoV-2 medication, Molnupiravir (M) and repurposed Ivermectin (IV) had been in contrast. The IC50 for the inhibition of viral replication had been zero.threeµM for M and a couple of.eightµM for IV. Each medication have good oral absorption, with M reaching peak plasma concentrations by 2 hours and IV by 5 hours. The plasma half life had been 7 hours for M and 81-91 hours for IV. M inhibits viral replication inducing viral mutagenesis in RdRp, inflicting viral error disaster and viral extinction. IV impacts viral cell entry, nuclear transport and inhibits replication through RdRp. IV has further impact to suppress cytokine…
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